Overarching objective: To evaluate if agrochemical exposures can affect children’s physiology, growth and mental health. We assess both short-term and long-term outcomes.
ESPINA is a prospective cohort study of children established in 2008 aimed at assessing the associations of exposures to pesticides with the development of children living in agricultural settings (Pedro Moncayo County, Ecuador). The 14-year follow-up of participants (adolescents and young adults) is scheduled for the summer of 2022. Our work includes health assessments including neurobehavior, mental health (internalizing/externalizing), endocrine, inflammation, hemodynamic, respiratory, enzymatic, and metabolomic. We rely on geospatial determinants of exposure as well as blood and urinary markers of exposures to PFAS, PCBs, PBDE flame retardants, DEET, and many pesticides including insecticides (organochlorine, organophosphate, pyrethroid, carbamate, neonicotinoid), herbicides (glyphosate, 2,4-Dichlorophenoxyacetic acid), and fungicides (dithiocarbamate, quinone outside inhibitors, azoles).