Cardiovascular Disease Outcomes

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Information on Clinical Cardiovascular Disease events and surgeries was gathered by self-report at research clinic visits and via annual mailers starting in 1971 and continuing through 2018.  The Rose Questionnaire was administered at Visits 2 through 12 and evaluated for angina and intermittent claudication scores.  Measures of Subclinical Cardiovascular Disease were obtained at research clinic visits beginning with Visit 3 and included carotid atherosclerosis, coronary artery calcification (measured at two time points on the same participants), and multiple measures of peripheral arterial disease.  Note: The Subclinical Cardiovascular Disease section of the RBS Archive is still under development; data will be available by October, 2019. 

See the Labs data group for traditional and novel CVD risk factor blood measures obtained at each research clinic visit.  See Physical Characteristics data group for physical measures obtained at each visit such as blood pressures, body size and body composition.

Validation of self-reported heart attack: In 1983,validation of self-reported heart attack (by chest pain, enzyme elevation, and electrocardiogram) was achieved for 72% of the 173 cases in which hospital records could be obtained. (1)

Validation of cardiovascular cause of death:  In one third of the cohort, all death certificates with any mention of CVD, hypertension, or diabetes were validated by interviews with next of kin, physicians and hospital records.  A mortality classification panel of cardiologists determined that these data supported the CVD diagnosis in 86% of cases reviewed. (1)

References

  1. Barrett-Connor E, Khaw KT. Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study. Circulation. 1988;78(3):539-45. PubMed PMID: 3409497.

Subclinical Cardiovascular Disease

Note: The Subclinical Cardiovascular Disease section of the RBS Archive is still under development; data will be available by October, 2019.